La SFBC est fière de vous présenter ses lauréats pour Euromedlab 2025. Nos jeunes biologistes ont du talent !
1 – SFBC/IFCC Charles Lefevre (Rennes)
2 – SFBC-SNIBE/EFLM* Morgane Ducastel (Paris-Cochin)
Service de Biochimie, Hôpital Cochin, AP-HP, Paris et Service de Rhumatologie, Hôpital Cochin, AP-HP, Paris
Résumé n°1 : Familial Hypocalciuric Hypercalcemia: comparison of biochemical index to differentiate patients with primary hyperparathyroidism.
Hypercalcémie hypocalciurique familiale : comparaison d’index biochimiques pour discriminer les patients atteints d’hyperparathyroïdie primitive.
L’hypercalcémie hypercalciurique familiale est une maladie génétique généralement asymptomatique du métabolisme phosphocalcique dont la présentation biologique est similaire à l’hyperparathyroïdie primitive. Cette étude vise à identifier l’index biochimique le plus pertinent pour différencier les patients FHH de ceux atteints de PHPT dans la pratique clinique courante.
Résumé n°2 : Ionized Calcium vs. Total Calcium and Corrected Calciums: Why Prioritize Ionized Calcium Measurement?
Calcium ionisé vs. calcium total et formules de correction : Pourquoi privilégier le dosage du calcium ionisé ?
Le calcium ionisé représente la forme biologiquement active du calcium circulant mais il n’est pas systématiquement mesuré car sa détermination nécessite un équipement spécifique et un traitement pré-analytique rigoureux. Le but de cette étude est de démontrer la pertinence du calcium ionisé par rapport au calcium total et aux calcémies corrigées dans l’investigation des anomalies du métabolisme phosphocalcique.
3 – SFBC-SNIBE Mondesert Etienne (Montpellier)
4 – SFBC Puravet Antoine (Clermont-Ferrand)
Service Biochimie et Génétique Moléculaire, CHU de Clermont-Ferrand
Université Clermont Auvergne, Faculté de médecine, CNRS 6293, INSERM 1103, IGRED, Clermont-Ferrand, France
Titre de la communication : Can the Association of the biomarkers GFAP and UCH-L1 Predict Intracranial injury after Mild Traumatic Brain Injury in Adults? A systematic review and meta-analysis
Résumé : A meta-analysis was performed to assess the prognostic value in the asscoiation of GFAP and CHU-L1 allows the exclusion of intracranial injury after mTBI in adults with 100% Se and negative. predictive value (NPV). Its routine use can theoretically reduce the number of CCT scans by 31%.
5 – SFBC Ouni Mohamed (Lille)
Interne en Biologie médicale (7ème semestre)
Service de Biochimie automatisée Proteines, CHU de Lille
Abstract 1 : Refining functional metabolism insights in chronic kidney disease : impact on Homocysteine and methylmalonic acid
Plasma homocysteine (Hcy) and methylmalonic acid (MMA) are used as functional markers of vitamin B9 and B12 status exploration. High levels of these markers are found in vitamin deficiency, in nitrous oxide intoxication, and for hereditary enzyme deficiencies.
In addition to these causes hyperhomocysteinemia (>12 µmol/L) and increased MMA levels (> 0,47 µmol/L) are often observed in renal failure. In order to investigate the frequency extent and variation of icreases in these parameters in patients with chronic kidney disease, our study explored at the levels found before and after dialysis.
Abstract 2 : Unraveling the causes of severe hyperhomocysteinemia : Beyond Genetics, a Focus on emerging factors
A major increase in plasma homocysteine (Hcys), greater than or equal to 100 umol/L (norm < 15 µmol/L), is usually considered a marker of hereditary diseases. Howerver, the frequency of major hyperhomocysteinemia due to secondary causes, such as functional deficiencies caused by nitrous oxide intoxication or vitamin deficiencies, has not been clearly etablished.
In order to better assess the importance of different etiologies, our study focused on determining the main causes of a major increase in plasma homocysteine.
6 – SFBC-SNIBE Favalelli Mathilde (Rennes)
7 – SFBC-SNIBE Kahouadji Samy (Clermont-Ferrand)
Assistant Hospitalier Universitaire
Service de biochimie et Génétique Moléculaire, CHU Clermont-Ferrand
Analytical and clinical evaluations of Snibe Maglumi* S100B assay
This study compared Snibe and Roche S100B assays in mild traumatic brain injury. While the Snibe assay is suitable to reduce unnecessary CT scans, further studies are required to determine a decision threshold, as results between assays are not interchangeable.
8 – SFBC François Stanislas (Paris-Bichat)
Interne en biologie médicale
Articles 1 : Hôpital Bichat Claude-Bernard service de Biochimie : CITRULLINE IN ACUTE MESENTERIC ISCHEMIA: A VIEW FROM CLINICAL PRACTICE
Mise en place du dosage d’un marqueur biologique (citrulline) dans le cadre du diagnostic des ischémies mésentériques aiguës.
Articles 2 : Hôpital Henri Mondor service de Biochimie (Laboratoire du globule rouge) : ERYTHROPOIETIC STIMULATION-INDEPENDENT APPROACH IN GLUCOSE 6 PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY SCREENING : REVISING THE WHO CLASSIFICATION
Exploration de la sensibilité et de la spécificité du dosage de la Glucose-6-Phosphate déshydrogénase (G6PD), pyruvate kinase, hexokinase et de leurs ratios afin d’affiner le diagnostic de déficit en G6PD et d’améliorer la classification clinique.
9 – SFBC Giraudeau Anne (Rennes)
10 – SFBC-SNIBE Carpentier Maxime (Nantes)
Assistant hospitalo-Universitaire
Laboratoire de Biochimie, CHU de Nantes, Hôtel-Dieu et Hôpital Guillaume et René Laënnec.
Equipe 4 : « Cardiometabolic Diseases », INSERM UMR 1087/CNRS UMR 6291, Institut du thorax, IRS – UN.
NfL as a Biomarker for Neurological Damage in Nitrous Oxide Abuse
Abstract
In recent years, the recreational misuse of nitrous oxide has significantly increased, becoming a public health concern in many countries. Diagnosis currently relies on clinical assessment and patient-reported consumption. The biological assessment of N₂O misuse is based on biochemical markers of vitamin B12 metabolism, total homocysteine and plasma methylmalonic acid. Unfortunately, these are neither specific nor sensitive. However, plasma neurofilament light chain (NfL), a well-established biomarker for assessing axonal damage, has never been studied in this context.
Our study aims to determine the utility of NfL, particularly with the recent improvements in its measurement in plasma, in the diagnosis and monitoring of neurological damage caused by nitrous oxide misuse.